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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2001-5-29
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pubmed:abstractText |
Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-kappaB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-kappaB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-ABL fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-JAK2 fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-JAK2 fusion protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
497
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
148-52
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11377430-Animals,
pubmed-meshheading:11377430-Cell Division,
pubmed-meshheading:11377430-Cell Line, Transformed,
pubmed-meshheading:11377430-Cell Survival,
pubmed-meshheading:11377430-Cell Transformation, Neoplastic,
pubmed-meshheading:11377430-DNA,
pubmed-meshheading:11377430-DNA-Binding Proteins,
pubmed-meshheading:11377430-Enzyme Inhibitors,
pubmed-meshheading:11377430-I-kappa B Proteins,
pubmed-meshheading:11377430-Interleukin-3,
pubmed-meshheading:11377430-Leukemia,
pubmed-meshheading:11377430-MAP Kinase Signaling System,
pubmed-meshheading:11377430-Mice,
pubmed-meshheading:11377430-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11377430-NF-kappa B,
pubmed-meshheading:11377430-Oncogene Proteins, Fusion,
pubmed-meshheading:11377430-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11377430-Phosphorylation,
pubmed-meshheading:11377430-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11377430-Protein-Tyrosine Kinases,
pubmed-meshheading:11377430-Proto-Oncogene Proteins,
pubmed-meshheading:11377430-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:11377430-Recombinant Proteins,
pubmed-meshheading:11377430-Signal Transduction,
pubmed-meshheading:11377430-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of the NF-kappaB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein.
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pubmed:affiliation |
Institut Cochin de Génétique Moléculaire (ICGM), INSERM U363, Paris, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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