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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-5-29
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pubmed:abstractText |
The relationships between structures and inhibitory activities of glycosidase inhibitors of gem-diamine 1-N-iminosugars in media of enzyme assays have been investigated. It has been proved that gem-diamine 1-N-iminosugar smoothly undergoes a structural change to a hydrated ketone or its derivative via a hemiaminal in the media (pH 5.0-6.3), and that the products generated in the media as well as the parent gem-diamine 1-N-iminosugars potently inhibit glycosidases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1091-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11377167-Animals,
pubmed-meshheading:11377167-Carbohydrate Metabolism,
pubmed-meshheading:11377167-Carbohydrates,
pubmed-meshheading:11377167-Diamines,
pubmed-meshheading:11377167-Enzyme Inhibitors,
pubmed-meshheading:11377167-Glycoside Hydrolases,
pubmed-meshheading:11377167-Hydrogen-Ion Concentration,
pubmed-meshheading:11377167-Imines,
pubmed-meshheading:11377167-Ketones,
pubmed-meshheading:11377167-Structure-Activity Relationship,
pubmed-meshheading:11377167-Time Factors,
pubmed-meshheading:11377167-alpha-L-Fucosidase
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pubmed:year |
2001
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pubmed:articleTitle |
Glycosidase inhibitors of gem-diamine 1-N-iminosugars. structures in media of enzyme assays.
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pubmed:affiliation |
Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
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pubmed:publicationType |
Journal Article
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