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pubmed-article:11376841pubmed:abstractTextEchoviruses (EV) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. In experiments with chimeric recombinant fusion proteins, both viruses bound to the I domain of the integrin VLA-2, and both required the same receptor residues for attachment. A full-length, infectious cDNA clone encoding EV1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the EV8 capsid. EV1 and 8 show 94% amino acid identity within the capsid region and are more similar to each other than to any other human picornavirus.lld:pubmed
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pubmed-article:11376841pubmed:articleTitleEchoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.lld:pubmed
pubmed-article:11376841pubmed:affiliationDivision of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, 1202 Abramson, 3516 Civic Center Boulevard, 19104-4318, Philadelphia, PA, USA.lld:pubmed
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