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rdf:type |
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lifeskim:mentions |
umls-concept:C0056111,
umls-concept:C0318396,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1145667,
umls-concept:C1514562,
umls-concept:C1521761,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2348205
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pubmed:issue |
1
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pubmed:dateCreated |
2001-5-29
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pubmed:abstractText |
Echoviruses (EV) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. In experiments with chimeric recombinant fusion proteins, both viruses bound to the I domain of the integrin VLA-2, and both required the same receptor residues for attachment. A full-length, infectious cDNA clone encoding EV1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the EV8 capsid. EV1 and 8 show 94% amino acid identity within the capsid region and are more similar to each other than to any other human picornavirus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0168-1702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11376841-Amino Acid Sequence,
pubmed-meshheading:11376841-Animals,
pubmed-meshheading:11376841-Binding Sites,
pubmed-meshheading:11376841-Capsid,
pubmed-meshheading:11376841-Cloning, Molecular,
pubmed-meshheading:11376841-DNA, Complementary,
pubmed-meshheading:11376841-DNA, Recombinant,
pubmed-meshheading:11376841-Enterovirus B, Human,
pubmed-meshheading:11376841-HeLa Cells,
pubmed-meshheading:11376841-Humans,
pubmed-meshheading:11376841-Mice,
pubmed-meshheading:11376841-Models, Molecular,
pubmed-meshheading:11376841-Molecular Sequence Data,
pubmed-meshheading:11376841-Phylogeny,
pubmed-meshheading:11376841-Protein Binding,
pubmed-meshheading:11376841-Protein Structure, Tertiary,
pubmed-meshheading:11376841-Receptors, Very Late Antigen,
pubmed-meshheading:11376841-Receptors, Virus,
pubmed-meshheading:11376841-Recombinant Fusion Proteins,
pubmed-meshheading:11376841-Sequence Homology, Amino Acid
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pubmed:year |
2001
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pubmed:articleTitle |
Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.
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pubmed:affiliation |
Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, 1202 Abramson, 3516 Civic Center Boulevard, 19104-4318, Philadelphia, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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