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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-5-29
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pubmed:abstractText |
Dystrophin provides mechanical reinforcement to the membranes of myocytes. Dystrophin abnormalities are known to cause cardiomyopathy and skeletal muscle disorders; however, the pathogenesis of these abnormalities remains unclear. Dystrophin-deficient skeletal muscle is vulnerable to stresses such as stretch and hypo-osmotic shock. We investigated whether the myocardium of dystrophin-deficient (mdx) mice shows increased vulnerability to acute pressure overload in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-15
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11376626-Animals,
pubmed-meshheading:11376626-Aorta,
pubmed-meshheading:11376626-Blood Pressure,
pubmed-meshheading:11376626-Cardiomyopathy, Dilated,
pubmed-meshheading:11376626-Dystrophin,
pubmed-meshheading:11376626-Heart Ventricles,
pubmed-meshheading:11376626-Hemodynamics,
pubmed-meshheading:11376626-Hypertension,
pubmed-meshheading:11376626-Hypertrophy, Left Ventricular,
pubmed-meshheading:11376626-Linear Models,
pubmed-meshheading:11376626-Male,
pubmed-meshheading:11376626-Mice,
pubmed-meshheading:11376626-Mice, Inbred C57BL,
pubmed-meshheading:11376626-Muscular Dystrophy, Animal,
pubmed-meshheading:11376626-Myocardium,
pubmed-meshheading:11376626-Stress, Mechanical
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pubmed:year |
2001
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pubmed:articleTitle |
Dystrophin-deficient myocardium is vulnerable to pressure overload in vivo.
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pubmed:affiliation |
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, 8908520, Kagoshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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