| pubmed-article:11376336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11376336 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11376336 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:11376336 | lifeskim:mentions | umls-concept:C0795635 | lld:lifeskim |
| pubmed-article:11376336 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:11376336 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11376336 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11376336 | pubmed:dateCreated | 2001-5-28 | lld:pubmed |
| pubmed-article:11376336 | pubmed:abstractText | The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes. | lld:pubmed |
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| pubmed-article:11376336 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11376336 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11376336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11376336 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11376336 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:11376336 | pubmed:author | pubmed-author:LeeK HKH | lld:pubmed |
| pubmed-article:11376336 | pubmed:author | pubmed-author:WileyD CDC | lld:pubmed |
| pubmed-article:11376336 | pubmed:author | pubmed-author:Wucherpfennig... | lld:pubmed |
| pubmed-article:11376336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11376336 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:11376336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11376336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11376336 | pubmed:pagination | 501-7 | lld:pubmed |
| pubmed-article:11376336 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11376336 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11376336 | pubmed:articleTitle | Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. | lld:pubmed |
| pubmed-article:11376336 | pubmed:affiliation | Laboratory of Molecular Medicine, The Department of Medicine, The Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:11376336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11376336 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11376336 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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