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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-5-28
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pubmed:abstractText |
The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11376336-Animals,
pubmed-meshheading:11376336-Binding Sites,
pubmed-meshheading:11376336-Crystallography, X-Ray,
pubmed-meshheading:11376336-Diabetes Mellitus, Type 1,
pubmed-meshheading:11376336-HLA-DQ Antigens,
pubmed-meshheading:11376336-Haplotypes,
pubmed-meshheading:11376336-Histocompatibility Antigens Class II,
pubmed-meshheading:11376336-Humans,
pubmed-meshheading:11376336-Immunodominant Epitopes,
pubmed-meshheading:11376336-Insulin,
pubmed-meshheading:11376336-Macromolecular Substances,
pubmed-meshheading:11376336-Mice,
pubmed-meshheading:11376336-Mice, Inbred NOD,
pubmed-meshheading:11376336-Models, Molecular,
pubmed-meshheading:11376336-Peptide Fragments,
pubmed-meshheading:11376336-Protein Conformation
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pubmed:year |
2001
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pubmed:articleTitle |
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
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pubmed:affiliation |
Laboratory of Molecular Medicine, The Department of Medicine, The Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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