| pubmed-article:11376126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11376126 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:11376126 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11376126 | pubmed:dateCreated | 2001-5-28 | lld:pubmed |
| pubmed-article:11376126 | pubmed:abstractText | In MCF-7 breast cancer cells, the insulin-like growth factor 1 receptor (IGF-1R) and the oestrogen receptor (ER) are coexpressed and the two signalling systems are engaged in a crosstalk that results in synergistic growth. However, coupling between the signalling cascades is poorly understood. Oestradiol enhances IGF-1R signalling by inducing the expression of insulin receptor substrate 1 (IRS-1), a substrate of the IGF-1R. Oestradiol induced expression of IRS-1 results in enhanced tyrosine phosphorylation of IRS-1 after IGF-1 stimulation, followed by enhanced mitogen activated protein kinase, phosphoinositide 3' kinase, and Akt activation. Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB). These effects are greatly diminished in SX13 cells, which exhibit a 50% reduction in IGF-1R expression but few functional IGF-1Rs at the surface. Oestradiol and IGF-1 regulate the expression of two cyclin dependent kinase inhibitors, p21 and p27, differently. Whereas IGF-1 increases p21 expression and reduces p27 expression, oestradiol has no effect on p21. In summary, in MCF-7 cells, oestrogen potentiates the effect of IGF-1 on IGF-1R signalling and its effects on certain cell cycle components. | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11376126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11376126 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11376126 | pubmed:issn | 1366-8714 | lld:pubmed |
| pubmed-article:11376126 | pubmed:author | pubmed-author:DupontJJ | lld:pubmed |
| pubmed-article:11376126 | pubmed:author | pubmed-author:Le RoithDD | lld:pubmed |
| pubmed-article:11376126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11376126 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:11376126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11376126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11376126 | pubmed:pagination | 149-54 | lld:pubmed |
| pubmed-article:11376126 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
| pubmed-article:11376126 | pubmed:meshHeading | pubmed-meshheading:11376126... | lld:pubmed |
