Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-28
pubmed:abstractText
In MCF-7 breast cancer cells, the insulin-like growth factor 1 receptor (IGF-1R) and the oestrogen receptor (ER) are coexpressed and the two signalling systems are engaged in a crosstalk that results in synergistic growth. However, coupling between the signalling cascades is poorly understood. Oestradiol enhances IGF-1R signalling by inducing the expression of insulin receptor substrate 1 (IRS-1), a substrate of the IGF-1R. Oestradiol induced expression of IRS-1 results in enhanced tyrosine phosphorylation of IRS-1 after IGF-1 stimulation, followed by enhanced mitogen activated protein kinase, phosphoinositide 3' kinase, and Akt activation. Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB). These effects are greatly diminished in SX13 cells, which exhibit a 50% reduction in IGF-1R expression but few functional IGF-1Rs at the surface. Oestradiol and IGF-1 regulate the expression of two cyclin dependent kinase inhibitors, p21 and p27, differently. Whereas IGF-1 increases p21 expression and reduces p27 expression, oestradiol has no effect on p21. In summary, in MCF-7 cells, oestrogen potentiates the effect of IGF-1 on IGF-1R signalling and its effects on certain cell cycle components.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10319328, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10323669, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10385618, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10417394, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10449601, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10453282, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10485619, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10498883, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10698680, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10705577, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10823945, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10967123, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-10985759, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-11029009, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-11044445, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-1497317, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-2174437, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-2553250, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-2553774, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-3865204, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7479773, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7529598, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7557388, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7624798, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7664648, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7954821, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-7958854, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8208295, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8491186, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8620534, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8646781, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8650195, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8897079, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-8943347, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9056422, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9106657, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9205078, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9388270, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9401207, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9494778, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9661601, http://linkedlifedata.com/resource/pubmed/commentcorrection/11376126-9832502
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclins, http://linkedlifedata.com/resource/pubmed/chemical/Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I, http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1, http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein, http://linkedlifedata.com/resource/pubmed/chemical/Tagln protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1366-8714
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-54
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11376126-Humans, pubmed-meshheading:11376126-Breast Neoplasms, pubmed-meshheading:11376126-Estradiol, pubmed-meshheading:11376126-Tyrosine, pubmed-meshheading:11376126-Phosphorylation, pubmed-meshheading:11376126-Female, pubmed-meshheading:11376126-Cell Division, pubmed-meshheading:11376126-Muscle Proteins, pubmed-meshheading:11376126-Tumor Cells, Cultured, pubmed-meshheading:11376126-Signal Transduction, pubmed-meshheading:11376126-Insulin-Like Growth Factor I, pubmed-meshheading:11376126-Microfilament Proteins, pubmed-meshheading:11376126-Cyclins, pubmed-meshheading:11376126-Phosphatidylinositol 3-Kinases, pubmed-meshheading:11376126-Receptor, IGF Type 1, pubmed-meshheading:11376126-Retinoblastoma Protein, pubmed-meshheading:11376126-Mitogen-Activated Protein Kinases, pubmed-meshheading:11376126-Cyclin D1
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