| pubmed-article:11375254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0132555 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11375254 | lifeskim:mentions | umls-concept:C1326358 | lld:lifeskim |
| pubmed-article:11375254 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11375254 | pubmed:dateCreated | 2001-5-25 | lld:pubmed |
| pubmed-article:11375254 | pubmed:abstractText | It was tested whether the inducible nitric oxide synthase (iNOS) pathway might be involved in lipopolysaccharides-(LPS)-induced up-regulation of L-arginine transport in rat alveolar macrophages (AM). AM were cultured in absence or presence of LPS. Nitrite accumulation was determined in culture media and cells were used to study [3H]-L-arginine uptake or to isolate RNA for RT - PCR. Culture in presence of LPS (1 microg ml(-1), 20 h) caused 11 fold increase of nitrite accumulation and 2.5 fold increase of [3H]-L-arginine uptake. The inducible NO synthase (iNOS) inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) present alone during culture had only marginal effects on [3H]-L-arginine uptake. However, AMT present during culture additionally to LPS, suppressed LPS-induced nitrite accumulation and LPS-stimulated [3H]-L-arginine uptake in the same concentration-dependent manner. AMT present only for the last 30 min of the culture period had similar effects on [3H]-L-arginine uptake. AMT present only during the uptake period also inhibited LPS-stimulated [3H]-L-arginine uptake, but with lower potency. The inhibitory effect of AMT could not be opposed by the NO releasing compound DETA NONOate. LPS caused an up-regulation of the mRNA for the cationic amino acid transporter CAT-2B, and this effect was not affected by AMT. AMT (100 microM) did not affect L-arginine transport studied by electrophysiological techniques in Xenopus laevis oocytes expressing either the human cationic amino acid transporter hCAT-1 or hCAT-2B. In conclusion, iNOS inhibition in rat AM abolished LPS-activated L-arginine uptake. This effect appears to be caused by reduced flow of L-arginine through the iNOS pathway. | lld:pubmed |
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| pubmed-article:11375254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11375254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11375254 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11375254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11375254 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11375254 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11375254 | pubmed:author | pubmed-author:NawrathHH | lld:pubmed |
| pubmed-article:11375254 | pubmed:author | pubmed-author:ClossE IEI | lld:pubmed |
| pubmed-article:11375254 | pubmed:author | pubmed-author:RackéKK | lld:pubmed |
| pubmed-article:11375254 | pubmed:author | pubmed-author:HammermannRR | lld:pubmed |
| pubmed-article:11375254 | pubmed:author | pubmed-author:StichnoteCC | lld:pubmed |
| pubmed-article:11375254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11375254 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:11375254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11375254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11375254 | pubmed:pagination | 379-86 | lld:pubmed |
| pubmed-article:11375254 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
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| pubmed-article:11375254 | pubmed:meshHeading | pubmed-meshheading:11375254... | lld:pubmed |
| pubmed-article:11375254 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11375254 | pubmed:articleTitle | Inhibition of nitric oxide synthase abrogates lipopolysaccharides-induced up-regulation of L-arginine uptake in rat alveolar macrophages. | lld:pubmed |
| pubmed-article:11375254 | pubmed:affiliation | Institute of Pharmacology and Toxicology, University of Bonn, Reuterstr. 2b, D-53113 Bonn, Germany. | lld:pubmed |
| pubmed-article:11375254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11375254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11375254 | lld:pubmed |
