|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0033684,
umls-concept:C0205314,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0679622,
umls-concept:C1414901,
umls-concept:C1414902,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2700640
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-5-25
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We have isolated, in guinea-pig endometrial cells, an estrogen-induced 1.8 kb RNA called gec1. Screening of a guinea-pig genomic library led to identification of gec1 gene consisting of 4 exons and 3 introns. Exon 1 contains the 5'UTR and the ATG initiation codon. A guinea-pig gec1 cDNA was obtained by 5'-RACE. The 351 bp coding sequence shares 76.8% identity with that of the human GABARAP 924 bp cDNA while UTRs of the two cDNAs differ. A gec1 probe from the 3'UTR revealed a 1.9 kb mRNA in human tissues and a human GEC1 cDNA was isolated from placenta. Its coding sequence shares 93 and 79% identity with that of guinea-pig gec1 and human GABARAP, respectively. The human and guinea-pig GEC1 proteins have 100% identity. GEC1 and GABARAP proteins have 87% identity and N terminus featuring a tubulin binding motif. Thus, estrogen-regulated gec1 is a new gene which could encode a microtubule-associated protein.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/GABARAP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2001 Academic Press.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
284
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
118-25
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11374880-3' Untranslated Regions,
pubmed-meshheading:11374880-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11374880-Animals,
pubmed-meshheading:11374880-Base Sequence,
pubmed-meshheading:11374880-Cloning, Molecular,
pubmed-meshheading:11374880-DNA, Complementary,
pubmed-meshheading:11374880-Estrogens,
pubmed-meshheading:11374880-Exons,
pubmed-meshheading:11374880-Female,
pubmed-meshheading:11374880-Gene Expression Regulation,
pubmed-meshheading:11374880-Genomic Library,
pubmed-meshheading:11374880-Guinea Pigs,
pubmed-meshheading:11374880-Humans,
pubmed-meshheading:11374880-Introns,
pubmed-meshheading:11374880-Microtubule-Associated Proteins,
pubmed-meshheading:11374880-Molecular Sequence Data,
pubmed-meshheading:11374880-Organ Specificity,
pubmed-meshheading:11374880-Placenta,
pubmed-meshheading:11374880-RNA, Messenger,
pubmed-meshheading:11374880-Sequence Analysis, DNA,
pubmed-meshheading:11374880-Sequence Homology, Amino Acid,
pubmed-meshheading:11374880-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11374880-Transcription, Genetic
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP.
|
|
pubmed:affiliation |
Institut d'Etude et de Transfert de Gènes, Bâtiment INSERM, Besançon, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
