Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-25
pubmed:abstractText
To evaluate the ability of arteriovenous carbon dioxide removal (AVCO2R) to maintain hemodynamic stability during treatment of adult respiratory distress syndrome (ARDS), we used our smoke/burn, LD40 sheep model of ARDS. With onset of ARDS (PaO2/FiO2 < 200) animals were randomized to AVCO2R (n = 20) or SHAM (n = 8). With AVCO2R, the carotid artery (10-14 F) and jugular vein (14-16 F) were cannulated; SHAM received identical management, sparing the vessels. AVCO2R maintained stable hemodynamics compared to SHAM at 48 hours; heart rate (114.8+/-6.1 vs. 110.1+/-11.0 beats/min.), mean arterial pressure (112+/-5.1 vs. 107.0+/-8.5 mm Hg), cardiac output (7.4+/-0.5 vs. 7.5+/-0.9 L/min.), pulmonary arterial pressure (26+/-2.4 vs. 21+/-1.3 mm Hg), pulmonary arterial wedge pressure (14.1+/-1.8 vs. 14.0+/-1.2 mm Hg), and central venous pressure (7+/-1.6 vs. 8+/-0.9 mm Hg). At 48 hours, AVCO2R allowed significant reductions (p<0.05) in minute ventilation (13.6+/-2.5 to 7.6+/-0.8 L/min); tidal volume (TV) (389.4+/-24.1 to 295.0+/-10.1 ml); peak inspiratory pressure (PIP) (25.4+/-9.2 to 18.8+/-2.5 cm H2O); RR (27.5+/-0.7 to 21.6+/-1.8 breaths/min); and FiO2 (0.96+/-0.00 to 0.48+/-0.2) while normocapnia was maintained. AVCO2R is an effective method of CO2 removal during severe respiratory failure that is hemodynamically well tolerated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1058-2916
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11374759-Age Factors, pubmed-meshheading:11374759-Animals, pubmed-meshheading:11374759-Blood Pressure, pubmed-meshheading:11374759-Burns, pubmed-meshheading:11374759-Carbon Dioxide, pubmed-meshheading:11374759-Cardiac Output, pubmed-meshheading:11374759-Central Venous Pressure, pubmed-meshheading:11374759-Disease Models, Animal, pubmed-meshheading:11374759-Extracorporeal Circulation, pubmed-meshheading:11374759-Female, pubmed-meshheading:11374759-Heart Rate, pubmed-meshheading:11374759-Hemodynamics, pubmed-meshheading:11374759-Prospective Studies, pubmed-meshheading:11374759-Pulmonary Wedge Pressure, pubmed-meshheading:11374759-Random Allocation, pubmed-meshheading:11374759-Respiration, Artificial, pubmed-meshheading:11374759-Respiratory Distress Syndrome, Adult, pubmed-meshheading:11374759-Smoke Inhalation Injury
pubmed:articleTitle
Hemodynamic stability during arteriovenous carbon dioxide removal for adult respiratory distress syndrome: a prospective randomized outcomes study in adult sheep.
pubmed:affiliation
Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston 77555-0528, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't