| pubmed-article:11374064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0074830 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:11374064 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:11374064 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11374064 | pubmed:dateCreated | 2001-5-25 | lld:pubmed |
| pubmed-article:11374064 | pubmed:abstractText | Somatostatin hyperpolarized rat pancreatic alpha-cells and inhibited spontaneous electrical activity by activating a low-conductance K+ channel (0.9 pS with physiological ionic gradients). This channel was insensitive to tolbutamide (a blocker of ATP-sensitive K+ channels) and apamin (an inhibitor of small-conductance Ca(2+)-activated K+ channels). Channel activation was prevented by pre-treating the cells with pertussis toxin, indicating the involvement of G-proteins. A direct interaction between an inhibitory G-protein and the somatostatin-activated K+ channel is suggested by the finding that intracellular application of guanosine 5'-O-(3-thiotriphosphate) (GTP gamma-S) and the G beta gamma subunit of G-proteins resulted in a transient stimulation of the current. Activation of the K+ current by somatostatin was inhibited by intracellular dialysis with specific antibodies to Gi1/2 and was not seen in cells treated with antisense oligonucleotides against G-proteins of the subtype Gi2. We conclude that somatostatin suppresses alpha-cell electrical activity by a Gi2-protein-dependent mechanism, which culminates in the activation of a sulphonylurea- and apamin-insensitive low-conductance K+ channel. | lld:pubmed |
| pubmed-article:11374064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11374064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11374064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11374064 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11374064 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:BuschardKK | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:GotfredsenC... | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:MaM CMC | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:RorsmanPP | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:BokvistKK | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:GromadaJJ | lld:pubmed |
| pubmed-article:11374064 | pubmed:author | pubmed-author:OlsenH LHL | lld:pubmed |
| pubmed-article:11374064 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11374064 | pubmed:volume | 442 | lld:pubmed |
| pubmed-article:11374064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11374064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11374064 | pubmed:pagination | 19-26 | lld:pubmed |
| pubmed-article:11374064 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:meshHeading | pubmed-meshheading:11374064... | lld:pubmed |
| pubmed-article:11374064 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11374064 | pubmed:articleTitle | Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells. | lld:pubmed |
| pubmed-article:11374064 | pubmed:affiliation | Novo Nordisk A/S, Novo Alle, 2880 Bagsvaerd, Denmark. jesper_gromada@lilly.com | lld:pubmed |
| pubmed-article:11374064 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11374064 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11374064 | lld:pubmed |
