| pubmed-article:11369792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11369792 | lifeskim:mentions | umls-concept:C0086313 | lld:lifeskim |
| pubmed-article:11369792 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11369792 | pubmed:dateCreated | 2001-5-22 | lld:pubmed |
| pubmed-article:11369792 | pubmed:abstractText | Major histocompatibility complex (MHC) class I-restricted CD8(+) T cells play a critical role in the protective immunity against Mycobacterium tuberculosis (Mtb). However, only a few Mtb peptides recognized by MHC class Ia-restricted CD8(+) T cells have been identified. Information on epitopes recognized by class Ib-restricted T cells is even more limited. M3 is an MHC class Ib molecule that preferentially presents N-formylated peptides to CD8(+) T cells. Because bacteria initiate protein synthesis with N-formyl methionine, the unique binding specificity of M3 makes it especially suitable for presenting these particular bacterial epitopes. We have scanned the full sequence of the Mtb genome for NH2-terminal peptides that share features with other M3-binding peptides. Synthetic peptides corresponding to these sequences were tested for their ability to bind to M3 in an immunofluorescence-based peptide-binding assay. Four of the N-formylated Mtb peptides were able to elicit cytotoxic T lymphocytes (CTLs) from mice immunized with peptide-coated splenocytes. The Mtb peptide-specific, M3-restricted CTLs lysed the Mtb-infected macrophages effectively, suggesting that these N-formylated Mtb peptides are presented as the naturally processed epitopes by Mtb-infected cells. Furthermore, T cells from Mtb-infected lungs, spleen, and lymph nodes responded to N-formylated Mtb peptides in an M3-restricted manner. Taken together, our data suggest that M3-restricted T cells may participate in the immune response to Mtb. | lld:pubmed |
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| pubmed-article:11369792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11369792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11369792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11369792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11369792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11369792 | pubmed:month | May | lld:pubmed |
| pubmed-article:11369792 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:LongJ GJG | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:WangC RCR | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:ChunTT | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:CoshD GDG | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:WandAA | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:FlyntJ RJR | lld:pubmed |
| pubmed-article:11369792 | pubmed:author | pubmed-author:SerbinaN VNV | lld:pubmed |
| pubmed-article:11369792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11369792 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:11369792 | pubmed:volume | 193 | lld:pubmed |
| pubmed-article:11369792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11369792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11369792 | pubmed:pagination | 1213-20 | lld:pubmed |
| pubmed-article:11369792 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:11369792 | pubmed:meshHeading | pubmed-meshheading:11369792... | lld:pubmed |
| pubmed-article:11369792 | pubmed:meshHeading | pubmed-meshheading:11369792... | lld:pubmed |
| pubmed-article:11369792 | pubmed:meshHeading | pubmed-meshheading:11369792... | lld:pubmed |
| pubmed-article:11369792 | pubmed:meshHeading | pubmed-meshheading:11369792... | lld:pubmed |
| pubmed-article:11369792 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11369792 | pubmed:articleTitle | Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:11369792 | pubmed:affiliation | Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA. | lld:pubmed |
| pubmed-article:11369792 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11369792 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
