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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-5-22
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pubmed:abstractText |
Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) is highly expressed in brown adipose tissue (BAT) and plays an important role in adaptive thermogenesis. The aim of this study was to assess the acute effect of a beta(3)-adrenergic agonist (Trecadrine) and leptin on the expression of PGC-1 and PPARgamma2 mRNA in BAT. Trecadrine produced a marked increase (4.5-fold) in PGC-1 mRNA compared to controls (P<0.001) without changes in PPARgamma2 mRNA, whereas leptin administration did not alter either PGC-1 or PPARgamma2 expression. These results show that selective stimulation of the beta(3)-adrenoceptor rapidly upregulates the expression of PGC-1 in brown adipocytes without a concomitant increase in PPARgamma2. Moreover, our results show that PGC-1 and PPARgamma2 expression in BAT seems not to be acutely regulated by leptin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Benzyl Alcohols,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein,
http://linkedlifedata.com/resource/pubmed/chemical/peroxisome-proliferator-activated...,
http://linkedlifedata.com/resource/pubmed/chemical/trecadrine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0303-7207
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11369446-Adipose Tissue, Brown,
pubmed-meshheading:11369446-Adrenergic beta-Agonists,
pubmed-meshheading:11369446-Animals,
pubmed-meshheading:11369446-Benzyl Alcohols,
pubmed-meshheading:11369446-Body Temperature,
pubmed-meshheading:11369446-Carrier Proteins,
pubmed-meshheading:11369446-Fasting,
pubmed-meshheading:11369446-Fatty Acids, Nonesterified,
pubmed-meshheading:11369446-Ion Channels,
pubmed-meshheading:11369446-Leptin,
pubmed-meshheading:11369446-Male,
pubmed-meshheading:11369446-Membrane Proteins,
pubmed-meshheading:11369446-Mitochondrial Proteins,
pubmed-meshheading:11369446-Oxygen Consumption,
pubmed-meshheading:11369446-RNA, Messenger,
pubmed-meshheading:11369446-Rats,
pubmed-meshheading:11369446-Rats, Wistar,
pubmed-meshheading:11369446-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11369446-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11369446-Transcription Factors,
pubmed-meshheading:11369446-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin.
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pubmed:affiliation |
Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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