Kinetochore microtubules are made early in mitosis and link chromosomal kinetochores to the spindle poles. They are required later to move the separated sister chromatids toward the opposite poles upon the onset of anaphase. Very little is known about proteins that are responsible for the connection between kinetochores and mitotic microtubules.
M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase.
Core Research for Evolutional Science and Technology Research Project, Department of Gene Mechanisms, Graduate School of Biostudies Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, 606-8502, Kyoto, Japan.
