Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-5-22
pubmed:abstractText
Effects of bimoclomol, the novel heat shock protein (HSP) coinducer, was studied in various mammalian cardiac and rabbit aortic preparations. Bimoclomol decreased the ST-segment elevation induced by coronary occlusion in anesthetized dogs (56% and 80% reduction with 1 and 5 mg/kg, respectively). In isolated working rat hearts, bimoclomol increased coronary flow (CF), decreased the reduction of cardiac output (CO) and left ventricular developed pressure (LVDP) developing after coronary occlusion, and prevented ventricular fibrillation (VF) during reperfusion. In rabbit aortic preparations, precontracted with phenylephrine, bimoclomol induced relaxation (EC(50)=214 microM). Bimoclomol produced partial relaxation against 20 mM KCl, however, bimoclomol failed to relax preparations precontracted with serotonin, PGF(2) or angiotensin II. All these effects were evident within a few minutes after application of bimoclomol. A rapid bimoclomol-induced compartmental translocation of the already preformed HSPs may explain the protective action of the compound.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11368893-Animals, pubmed-meshheading:11368893-Aorta, pubmed-meshheading:11368893-Blood Pressure, pubmed-meshheading:11368893-Cardiac Output, pubmed-meshheading:11368893-Cardiovascular System, pubmed-meshheading:11368893-Coronary Disease, pubmed-meshheading:11368893-Coronary Vessels, pubmed-meshheading:11368893-Dogs, pubmed-meshheading:11368893-Electrocardiography, pubmed-meshheading:11368893-Female, pubmed-meshheading:11368893-Heart Rate, pubmed-meshheading:11368893-Heart Ventricles, pubmed-meshheading:11368893-Imides, pubmed-meshheading:11368893-Ischemia, pubmed-meshheading:11368893-Male, pubmed-meshheading:11368893-Models, Animal, pubmed-meshheading:11368893-Myocardial Contraction, pubmed-meshheading:11368893-Pyridines, pubmed-meshheading:11368893-Rabbits, pubmed-meshheading:11368893-Rats, pubmed-meshheading:11368893-Rats, Wistar, pubmed-meshheading:11368893-Regional Blood Flow
pubmed:year
2000
pubmed:articleTitle
In vivo and in vitro acute cardiovascular effects of bimoclomol.
pubmed:affiliation
Biorex Research and Development Co., PO Box 348, H-8201, Veszprém-Szabadságpuszta, Hungary.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't