Linked Life Data

11361470

Source:http://linkedlifedata.com/resource/pubmed/id/11361470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-4-10
pubmed:abstractText
In three groups of children, aged 4-6 years (i.e., human immunodeficiency virus [HIV]-negative controls, HIV-seropositive, and dually HIV/hepatitis C virus (HCV)-seropositive), two types of immunological investigations in blood cells were performed: (a) numerical assays, consisting of flow cytometric measurement of different lymphocyte sets or subsets, as follows: CD3+, CD19+, CD4+, CD16+/CD56+; (b) functional assays, consisting of interleukin-1 (IL-1) levels as well as natural killer (NK)-cell dependent cytotoxicity, in CD14+, or CD16+/CD56+ sorted cells, respectively. Results revealed, in addition to the classic markers (i.e., lower numbers of CD4+ cells and a decreased CD4+/CD8+ ratio in both infected groups of subjects) other findings, as follows: increased numbers of CD8+ cells in dually infected children, accompanied by a lower CD4+/CD8+ ratio, as compared to HIV-infected alone; diminished numbers of CD16+/CD56+ cells in both groups of infected patients were correlated with a lower NK-cell cytotoxicity rate; a reduced capacity for IL-1 synthesis of sorted macrophages both in HIV-only and in HIV/HCV-seropositive subjects, but significantly more marked in dually infected children. The importance of the present data in the immune monitoring of AIDS disease in a pediatric population is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
X
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1045-5418
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Different patterns of some systemic immunological cell markers in HIV only, and HIV/hepatitis C-infected children.
pubmed:affiliation
Department of Microbiology and Immunology, Faculty of Medicine Craiova, Romania.
pubmed:publicationType
Journal Article