Source:http://linkedlifedata.com/resource/pubmed/id/11359854
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2001-5-21
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| pubmed:abstractText |
Several studies have provided indirect evidence in support of a role for beta cell-specific Th2 cells in regulating insulin-dependent diabetes (IDDM). Whether a homogeneous population of Th2 cells having a defined beta cell Ag specificity can prevent or suppress autoimmune diabetes is still unclear. In fact, recent studies have demonstrated that beta cell-specific Th2 cell clones can induce IDDM. In this study we have established Th cell clones specific for glutamic acid decarboxylase 65 (GAD65), a known beta cell autoantigen, from young unimmunized nonobese diabetic (NOD) mice. Adoptive transfer of a GAD65-specific Th2 cell clone (characterized by the secretion of IL-4, IL-5, and IL-10, but not IFN-gamma or TGF-beta) into 2- or 12-wk-old NOD female recipients prevented the progression of insulitis and subsequent development of overt IDDM. This prevention was marked by the establishment of a Th2-like cytokine profile in response to a panel of beta cell autoantigens in cultures established from the spleen and pancreatic lymph nodes of recipient mice. The immunoregulatory function of a given Th cell clone was dependent on the relative levels of IFN-gamma vs IL-4 and IL-10 secreted. These results provide direct evidence that beta cell-specific Th2 cells can indeed prevent and suppress autoimmune diabetes in NOD mice.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
|
| pubmed:volume |
166
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6925-36
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11359854-Adoptive Transfer,
pubmed-meshheading:11359854-Age of Onset,
pubmed-meshheading:11359854-Animals,
pubmed-meshheading:11359854-Cell Culture Techniques,
pubmed-meshheading:11359854-Cell Movement,
pubmed-meshheading:11359854-Clone Cells,
pubmed-meshheading:11359854-Cytokines,
pubmed-meshheading:11359854-Diabetes Mellitus, Type 1,
pubmed-meshheading:11359854-Epitopes, T-Lymphocyte,
pubmed-meshheading:11359854-Female,
pubmed-meshheading:11359854-Glutamate Decarboxylase,
pubmed-meshheading:11359854-Interleukin-4,
pubmed-meshheading:11359854-Islets of Langerhans,
pubmed-meshheading:11359854-Isoenzymes,
pubmed-meshheading:11359854-Mice,
pubmed-meshheading:11359854-Mice, Inbred NOD,
pubmed-meshheading:11359854-Mice, SCID,
pubmed-meshheading:11359854-Spleen,
pubmed-meshheading:11359854-T-Lymphocyte Subsets,
pubmed-meshheading:11359854-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:11359854-Th2 Cells
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| pubmed:year |
2001
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| pubmed:articleTitle |
A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice.
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| pubmed:affiliation |
Department of Microbiology and Immunology, Mary Ellen Jones Building, Room 804, Campus Box 7290, University of North Carolina, Chapel Hill, NC 27599-7290, USA. mtisch@med.unc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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