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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0021758,
umls-concept:C0035696,
umls-concept:C0039097,
umls-concept:C0039194,
umls-concept:C0205217,
umls-concept:C0456603,
umls-concept:C0524914,
umls-concept:C0553662,
umls-concept:C1332714,
umls-concept:C1413190,
umls-concept:C1422405,
umls-concept:C1422515,
umls-concept:C1515021
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pubmed:issue |
11
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pubmed:dateCreated |
2001-5-21
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pubmed:abstractText |
To understand the mechanisms that promote recruitment and survival of T cells within the pediatric inflamed joint, we have studied the expression of CCR4 and CCR5 on synovial fluid T cells and matched peripheral blood samples from juvenile rheumatoid arthritis (JRA) patients using three-color flow cytometric analysis. Thymus- and activation-regulated chemokine and macrophage-derived chemokine, ligands for CCR4, were measured by ELISA in JRA synovial fluid, JRA plasma, adult rheumatoid arthritis synovial fluid, and normal plasma. IL-4 and IFN-gamma mRNA production was assessed in CD4+/CCR4+ and CD4+/CCR4(-) cell subsets. We found accumulations of both CCR4+ and CCR5+ T cells in JRA synovial fluids and a correlation for increased numbers of CCR4+ T cells in samples collected early in the disease process. Thymus- and activation-regulated chemokine was detected in JRA synovial fluid and plasma samples, but not in adult rheumatoid arthritis synovial fluid or control plasma. Macrophage-derived chemokine was present in all samples. CD4+/CCR4+ synovial lymphocytes produced more IL-4 and less IFN-gamma than CD4+/CCR4(-) cells. These findings suggest that CCR4+ T cells in the JRA joint may function early in disease in an anti-inflammatory capacity through the production of type 2 cytokines and may play a role in determining disease phenotype.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL17 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCL22 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL17,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL22,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6899-906
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11359851-Adolescent,
pubmed-meshheading:11359851-Adult,
pubmed-meshheading:11359851-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:11359851-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11359851-Chemokine CCL17,
pubmed-meshheading:11359851-Chemokine CCL22,
pubmed-meshheading:11359851-Chemokines, CC,
pubmed-meshheading:11359851-Child,
pubmed-meshheading:11359851-Child, Preschool,
pubmed-meshheading:11359851-Cytokines,
pubmed-meshheading:11359851-Female,
pubmed-meshheading:11359851-Flow Cytometry,
pubmed-meshheading:11359851-Humans,
pubmed-meshheading:11359851-Immunophenotyping,
pubmed-meshheading:11359851-Interferon-gamma,
pubmed-meshheading:11359851-Interleukin-4,
pubmed-meshheading:11359851-Ligands,
pubmed-meshheading:11359851-Macrophages,
pubmed-meshheading:11359851-Male,
pubmed-meshheading:11359851-RNA, Messenger,
pubmed-meshheading:11359851-Receptors, CCR4,
pubmed-meshheading:11359851-Receptors, Chemokine,
pubmed-meshheading:11359851-Synovial Fluid,
pubmed-meshheading:11359851-T-Lymphocyte Subsets
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pubmed:year |
2001
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pubmed:articleTitle |
Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios.
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pubmed:affiliation |
William S. Rowe Division of Rheumatology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. thoms0@chmcc.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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