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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-5-18
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pubmed:abstractText |
We previously described a general class of DNA polyintercalators in which 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) intercalating units are connected via peptide linkers, resulting in the first known tetrakis- and octakis-intercalators. We showed further that changes in the composition of the peptide tether result in novel DNA binding site specificities. We now examine in detail the DNA binding mode and sequence specific recognition of Compound 1, an NDI bis-intercalator containing the peptide linker gly-gly-gly-lys.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-25
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11358689-Base Sequence,
pubmed-meshheading:11358689-Binding Sites,
pubmed-meshheading:11358689-DNA Primers,
pubmed-meshheading:11358689-Imides,
pubmed-meshheading:11358689-Intercalating Agents,
pubmed-meshheading:11358689-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11358689-Models, Molecular,
pubmed-meshheading:11358689-Molecular Conformation,
pubmed-meshheading:11358689-Naphthalenes,
pubmed-meshheading:11358689-Peptides,
pubmed-meshheading:11358689-Protein Footprinting,
pubmed-meshheading:11358689-Static Electricity
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pubmed:year |
2001
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pubmed:articleTitle |
Peptide bis-intercalator binds DNA via threading mode with sequence specific contacts in the major groove.
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pubmed:affiliation |
Department of Chemistry and Biochemistry, The University of Texas at Austin, 78722, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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