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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-5-18
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pubmed:abstractText |
Estrogens are essential regulators in the development and control of reproductive functions. The estrogenic signal is now known to be transduced by two estrogen receptors, ERalpha and ERbeta. Hormone-dependent transcriptional activation of ER and other nuclear receptors involves assembly of a coactivation complex which includes various cofactors such as the steroid receptor-coactivators (SRC) and CREB binding protein (CBP). Our findings on ERbeta have revealed a ligand-independent activation pathway which involves growth factor-mediated phosphorylation of ERbeta activation function-1 (AF-1) and subsequent recruitment of SRC-1 independently of the presence of estrogens. The presence of the cointegrator CBP is also shown to potentiate the SRC-1-mediated ERbeta ligand-independent activation, suggesting that CBP may participate in unliganded ERbeta coactivation. These findings demonstrate the ability of alternate signaling pathways to mediate coregulator assembly, hence resulting in ligand-independent activation of ERbeta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CREB-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/CREBBP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-0760
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11358671-CREB-Binding Protein,
pubmed-meshheading:11358671-Cell Line,
pubmed-meshheading:11358671-Estrogen Receptor beta,
pubmed-meshheading:11358671-Histone Acetyltransferases,
pubmed-meshheading:11358671-Humans,
pubmed-meshheading:11358671-Ligands,
pubmed-meshheading:11358671-Nuclear Proteins,
pubmed-meshheading:11358671-Nuclear Receptor Coactivator 1,
pubmed-meshheading:11358671-Phosphorylation,
pubmed-meshheading:11358671-Receptors, Estrogen,
pubmed-meshheading:11358671-Signal Transduction,
pubmed-meshheading:11358671-Trans-Activators,
pubmed-meshheading:11358671-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta.
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pubmed:affiliation |
Ste-Justine Hospital Research Center, University of Montreal, Montréal, QC, Canada H3T 1C5. atremblay@justine.umontreal.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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