Linked Life Data

11358370

Source:http://linkedlifedata.com/resource/pubmed/id/11358370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-5-18
pubmed:abstractText
There are many examples of O2-sensitive solute transport in vertebrate red cells. The response is selective, specific, and conserved across the entire vertebrate spectrum. A number of possible physiological roles have been proposed, but abnormal responses to O2 may also be important pathologically. Significant alterations in O2 dependence of red cell cation transport are observed in sickle cell disease (and also following exposure to oxidants) and probably contribute to its pathophysiology. In this paper, we review some of the features of O2-sensitive solute transporters in red cells and possible reasons for the abnormal response in sickle cells. Our aim is to identify specific, novel pharmacological inhibitors of these abnormal pathways and thereby ameliorate the disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1079-9796
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Academic Press.
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Oxygen-sensitive cation transport in sickle cells.
pubmed:affiliation
Department of Physiology, University of London, London, Tooting, SW17 0RE, United Kingdom. jsgibson@sghms.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't