|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6835
|
|
pubmed:dateCreated |
2001-5-17
|
|
pubmed:abstractText |
Wnt glycoproteins have been implicated in diverse processes during embryonic patterning in metazoa. They signal through frizzled-type seven-transmembrane-domain receptors to stabilize beta-catenin. Wnt signalling is antagonized by the extracellular Wnt inhibitor dickkopf1 (dkk1), which is a member of a multigene family. dkk1 was initially identified as a head inducer in Xenopus embryos but the mechanism by which it blocks Wnt signalling is unknown. LDL-receptor-related protein 6 (LRP6) is required during Wnt/beta-catenin signalling in Drosophila, Xenopus and mouse, possibly acting as a co-receptor for Wnt. Here we show that LRP6 (ref. 7) is a specific, high-affinity receptor for Dkk1 and Dkk2. Dkk1 blocks LRP6-mediated Wnt/beta-catenin signalling by interacting with domains that are distinct from those required for Wnt/Frizzled interaction. dkk1 and LRP6 interact antagonistically during embryonic head induction in Xenopus where LRP6 promotes the posteriorizing role of Wnt/beta-catenin signalling. Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DKK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DKK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DKK3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dkk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dkk2 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/LRP6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lrp6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-catenin protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/dkk1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/dkk1 protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/frizzled-8 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/wnt8a protein, zebrafish
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
411
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
321-5
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11357136-Animals,
pubmed-meshheading:11357136-Binding Sites,
pubmed-meshheading:11357136-Cell Line,
pubmed-meshheading:11357136-Cytoskeletal Proteins,
pubmed-meshheading:11357136-Embryo, Nonmammalian,
pubmed-meshheading:11357136-Embryonic Induction,
pubmed-meshheading:11357136-Head,
pubmed-meshheading:11357136-Humans,
pubmed-meshheading:11357136-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11357136-Low Density Lipoprotein Receptor-Related Protein-1,
pubmed-meshheading:11357136-Low Density Lipoprotein Receptor-Related Protein-6,
pubmed-meshheading:11357136-Precipitin Tests,
pubmed-meshheading:11357136-Protein Binding,
pubmed-meshheading:11357136-Protein Structure, Tertiary,
pubmed-meshheading:11357136-Proteins,
pubmed-meshheading:11357136-Proto-Oncogene Proteins,
pubmed-meshheading:11357136-RNA, Messenger,
pubmed-meshheading:11357136-Receptors, Cell Surface,
pubmed-meshheading:11357136-Receptors, Immunologic,
pubmed-meshheading:11357136-Receptors, LDL,
pubmed-meshheading:11357136-Recombinant Fusion Proteins,
pubmed-meshheading:11357136-Sequence Deletion,
pubmed-meshheading:11357136-Signal Transduction,
pubmed-meshheading:11357136-Substrate Specificity,
pubmed-meshheading:11357136-Trans-Activators,
pubmed-meshheading:11357136-Wnt Proteins,
pubmed-meshheading:11357136-Xenopus Proteins,
pubmed-meshheading:11357136-Xenopus laevis,
pubmed-meshheading:11357136-Zebrafish Proteins,
pubmed-meshheading:11357136-beta Catenin
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
|
|
pubmed:affiliation |
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
