| pubmed-article:11356610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C1416585 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C1416587 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:11356610 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:11356610 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11356610 | pubmed:dateCreated | 2001-5-17 | lld:pubmed |
| pubmed-article:11356610 | pubmed:abstractText | The cardiac M2 muscarinic receptor/G protein/K+ channel system was studied in neonatal rat atrial cells cultured with and without 10 microM carbachol (CCh) for 24 h. Channel activity in CCh-pretreated cells was substantially reduced as a result of long-term desensitization regardless of whether the channel was activated by ACh in cell-attached patches or GTP in inside-out patches. Channel activity in CCh-pretreated cells was also low when the receptor was bypassed and the G protein and channel were directly activated by [gamma-S]GTP or both the receptor and G protein were bypassed and the channel was directly activated by trypsin. Finally, in CCh-pretreated cells, the whole cell K+ current was low when the channel was activated via the independent adenosine receptor. This suggests that the channel is involved in long-term desensitization. However, in CCh-pretreated cells, although the receptor was internalized, there was no internalization of the channel. We suggest that the function of the muscarinic K+ channel declines in long-term desensitization of the cardiac M2 muscarinic receptor/G protein/K+ channel system. | lld:pubmed |
| pubmed-article:11356610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11356610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11356610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11356610 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11356610 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:11356610 | pubmed:author | pubmed-author:BoyettM RMR | lld:pubmed |
| pubmed-article:11356610 | pubmed:author | pubmed-author:ShueVV | lld:pubmed |
| pubmed-article:11356610 | pubmed:author | pubmed-author:YamanushiT... | lld:pubmed |
| pubmed-article:11356610 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11356610 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11356610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11356610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11356610 | pubmed:pagination | H2554-62 | lld:pubmed |
| pubmed-article:11356610 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11356610 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11356610 | pubmed:articleTitle | Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+ channels. | lld:pubmed |
| pubmed-article:11356610 | pubmed:affiliation | School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom. | lld:pubmed |
| pubmed-article:11356610 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11356610 | lld:pubmed |
