Linked Life Data

11356260

Source:http://linkedlifedata.com/resource/pubmed/id/11356260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-5-17
pubmed:abstractText
We investigated whether plastic changes occurred in the organization of the vestibular efferent network in the rat utricle during a 17-day episode of microgravity, from postnatal (PN) day 8 to PN23, and on return to earth on PN25. We also determined the normal pattern of efferent development from birth to PN25. Immunofluorescence experiments were performed with a specific biochemical marker of the efferent system, the calcitonin gene-related peptide (CGRP), and vibratome sections of the utricles were analyzed by laser scanning confocal microscopy. At birth, a few efferent fibers were detected beneath the sensory epithelium. These then massively invaded the epithelium between PN2 and PN4. At the time of launch, PN8, most fiber paths in the utricular epithelium, after following transient courses (towards the epithelial surface for example) returned to the base and were stabilized in the lower part of the epithelium, in which they established synaptic contacts with sensory cells, except at a few immature locations. The main difference between this stage (on PN8) and subsequent more mature stages was the lower density of fibers and synapses in the utricle. The maturation of the vestibular efferent system was similar in microgravity and on the ground. Thus, maturation of the efferent system between PN8 and PN23 was not sensitive to a change in gravitational environment. These results suggest that periods of microgravity at earlier stages are required to identify critical periods in peripheral vestibular system development.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Development of the rat efferent vestibular system on the ground and in microgravity.
pubmed:affiliation
INSERM 432, UM 2, Place E. Bataillon 34095 Cedex 05, Montpellier, France. dememes@univ-montp2.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't