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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0008838,
umls-concept:C0012854,
umls-concept:C0032207,
umls-concept:C0043240,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0221198,
umls-concept:C0332324,
umls-concept:C0332325,
umls-concept:C0334227,
umls-concept:C0374711,
umls-concept:C0439855,
umls-concept:C0441655,
umls-concept:C0596402,
umls-concept:C1140680,
umls-concept:C1705181
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pubmed:issue |
10
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pubmed:dateCreated |
2001-5-17
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pubmed:abstractText |
A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464. Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N- ras) level were observed between BBR 3464 and CDDP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BBR 3464,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ERCC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Organoplatinum Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/PMS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Cancer Research Campaign.
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1387-90
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pubmed:dateRevised |
2009-9-11
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pubmed:meshHeading |
pubmed-meshheading:11355952-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11355952-Adenosine Triphosphatases,
pubmed-meshheading:11355952-Antineoplastic Agents,
pubmed-meshheading:11355952-Base Pair Mismatch,
pubmed-meshheading:11355952-Carrier Proteins,
pubmed-meshheading:11355952-Cell Survival,
pubmed-meshheading:11355952-Cisplatin,
pubmed-meshheading:11355952-DNA Repair,
pubmed-meshheading:11355952-DNA Repair Enzymes,
pubmed-meshheading:11355952-DNA-Binding Proteins,
pubmed-meshheading:11355952-Drug Resistance, Neoplasm,
pubmed-meshheading:11355952-Endonucleases,
pubmed-meshheading:11355952-Female,
pubmed-meshheading:11355952-Humans,
pubmed-meshheading:11355952-Neoplasm Proteins,
pubmed-meshheading:11355952-Nuclear Proteins,
pubmed-meshheading:11355952-Organoplatinum Compounds,
pubmed-meshheading:11355952-Ovarian Neoplasms,
pubmed-meshheading:11355952-Polymerase Chain Reaction,
pubmed-meshheading:11355952-Proteins,
pubmed-meshheading:11355952-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions.
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pubmed:affiliation |
Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.
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pubmed:publicationType |
Journal Article
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