| pubmed-article:11355881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11355881 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11355881 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:11355881 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11355881 | lifeskim:mentions | umls-concept:C0074002 | lld:lifeskim |
| pubmed-article:11355881 | lifeskim:mentions | umls-concept:C0139718 | lld:lifeskim |
| pubmed-article:11355881 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11355881 | pubmed:dateCreated | 2001-5-17 | lld:pubmed |
| pubmed-article:11355881 | pubmed:abstractText | The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 microM salsolinol induced a 50% survival decrease). Incubation of RCSN-3 cells with 100 micro;M dicoumarol and salsolinol significantly decreased cell survival by 2.5-fold (P < 0.001), contrasting with a negligible effect on RCHT cells, which exhibited nearly a 5-fold lower nomifensine-insensitive dopamine uptake. The levels of catalase and glutathione peroxidase mRNA were decreased when RCSN-3 cells were treated with 100 microM salsolinol alone or in the presence of 100 microM dicoumarol. In vitro oxidation of salsolinol to o-quinone catalyzed by lactoperoxidase gave the quinone methide and 1,2-dihydro-1-methyl-6,7-isoquinoline diol as final products of salsolinol oxidation as determined by NMR analysis. Evidence of the formation of salsolinol o-semiquinone radical has been provided by ESR studies during one-electron oxidation of salsolinol catalyzed by lactoperoxidase. | lld:pubmed |
| pubmed-article:11355881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11355881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11355881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11355881 | pubmed:month | May | lld:pubmed |
| pubmed-article:11355881 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:MetodiewaDD | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:CaviedesRR | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:Segura-Aguila... | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:CaviedesPP | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:WelchC JCJ | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:ParisII | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:Olea-AzarCC | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:Dagnino-Subia... | lld:pubmed |
| pubmed-article:11355881 | pubmed:author | pubmed-author:Martinez-Alva... | lld:pubmed |
| pubmed-article:11355881 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11355881 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11355881 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:11355881 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:11355881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11355881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11355881 | pubmed:pagination | 1069-76 | lld:pubmed |
| pubmed-article:11355881 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11355881 | pubmed:meshHeading | pubmed-meshheading:11355881... | lld:pubmed |
| pubmed-article:11355881 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11355881 | pubmed:articleTitle | Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival. | lld:pubmed |
| pubmed-article:11355881 | pubmed:affiliation | Programme of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile. | lld:pubmed |
| pubmed-article:11355881 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11355881 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
