Linked Life Data

11355564

Source:http://linkedlifedata.com/resource/pubmed/id/11355564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-5-17
pubmed:abstractText
A randomized controlled trial in KwaZulu-Natal (South Africa) of 428 primary-school pupils (stratified into 6 groups by age, sex and intervention) measured the effect of different anthelmintic treatments and iron supplementation regimens provided twice at 6-monthly intervals for 1 year (1996/97). Half the pupils received iron supplementation (ferrous fumarate 200 mg weekly for 10 weeks). Pupils received 2 anthelmintic regimens, either (i) albendazole 400 mg plus praziquantel 40 mg/kg or (ii) albendazole 400 mg on 3 consecutive days plus praziquantel 40 mg/kg or (iii) placebo. Baseline prevalences of Ascaris 55.9%, Trichuris 83.6%, hookworm spp. 59.4%, were reduced after 12 months for single-dose albendazole treatment to Ascaris 17.4% (P < 0.005), Trichuris 61.5% (NS), hookworm spp. 0% (P < 0.005), and for triple-dose albendazole treatment to Ascaris 14.8% (P < 0.005), Trichuris 25.0% (P < 0.01), hookworm 0% (P < 0.005). Schistosoma haematobium 43.4% was reduced among treated groups to 8.3% (P < 0.005). There were no significant changes in the anthropometry of the different treatment groups at either 6 or 12 months post treatment. Twelve months after treatment there was a significant increase in haemoglobin levels (P = 0.02) among pupils receiving triple-dose albendazole, praziquantel and ferrous fumarate; pupils receiving no anthelmintic treatment showed a significant decrease as did pupils who received triple-dose albendazole and praziquantel but no iron. Regular 6-monthly anthelmintic treatment significantly reduced the prevalence of Ascaris, hookworm spp. and S. haematobium infections (P < 0.05). Triple-dose treatment for Trichuris was significantly more effective than a single dose of albendazole 400 mg (P = 0.002). In areas with schistosomiasis, hookworm infection and high prevalence of Trichuris infection, combination treatment with praziquantel, triple-dose albendazole, plus iron supplementation, is likely to improve pupils' health and haemoglobin levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0035-9203
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11355564-Adolescent, pubmed-meshheading:11355564-Albendazole, pubmed-meshheading:11355564-Anemia, pubmed-meshheading:11355564-Anthelmintics, pubmed-meshheading:11355564-Ascariasis, pubmed-meshheading:11355564-Body Height, pubmed-meshheading:11355564-Child, pubmed-meshheading:11355564-Double-Blind Method, pubmed-meshheading:11355564-Drug Combinations, pubmed-meshheading:11355564-Female, pubmed-meshheading:11355564-Helminthiasis, pubmed-meshheading:11355564-Hemoglobins, pubmed-meshheading:11355564-Humans, pubmed-meshheading:11355564-Iron, pubmed-meshheading:11355564-Male, pubmed-meshheading:11355564-Praziquantel, pubmed-meshheading:11355564-Regression Analysis, pubmed-meshheading:11355564-Risk Factors, pubmed-meshheading:11355564-Schistosomiasis haematobia, pubmed-meshheading:11355564-Trichuriasis
pubmed:articleTitle
The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal, South Africa: a randomized controlled trial.
pubmed:affiliation
Departments of Community Health and Haematology, Faculty of Medicine, University of Natal, Private Bag 7, Congella 4013, South Africa. taylor@med.und.ac.za
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't