|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2001-5-16
|
|
pubmed:abstractText |
The synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented. The 7-methoxyindazole, although less potent than 7-NI, is the most active compound of the series in an in vitro enzymatic assay of neuronal nitric oxide synthase activity. This result shows that the nitro-substitution is not indispensable to the biological activity of the indazole ring. 7-Methoxyindazole possesses in vivo NOS inhibitory as well and related antinociceptive properties.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1153-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11354365-Analgesics,
pubmed-meshheading:11354365-Animals,
pubmed-meshheading:11354365-Arginine,
pubmed-meshheading:11354365-Cerebellum,
pubmed-meshheading:11354365-Dose-Response Relationship, Drug,
pubmed-meshheading:11354365-Electrons,
pubmed-meshheading:11354365-Enzyme Inhibitors,
pubmed-meshheading:11354365-Indazoles,
pubmed-meshheading:11354365-Mice,
pubmed-meshheading:11354365-Nitric Oxide Synthase,
pubmed-meshheading:11354365-Nitric Oxide Synthase Type I,
pubmed-meshheading:11354365-Pain Measurement,
pubmed-meshheading:11354365-Rats,
pubmed-meshheading:11354365-Structure-Activity Relationship
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
|
|
pubmed:affiliation |
CNRS UMR 6551, Université de Caen, France. rault@pharmacie.unicaen.fr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
