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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-5-16
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pubmed:abstractText |
A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BermanJ MJM,
pubmed-author:BirkemoLL,
pubmed-author:CroomD KDK,
pubmed-author:DezubeMM,
pubmed-author:ErvinG NGN,
pubmed-author:GrizzleM KMK,
pubmed-author:JamesM KMK,
pubmed-author:JohnsonM FMF,
pubmed-author:QueenK LKL,
pubmed-author:ROUSSS,
pubmed-author:RimeleT JTJ,
pubmed-author:SherrillR GRG,
pubmed-author:VanmiddlesworthFF
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1145-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11354363-Animals,
pubmed-meshheading:11354363-Appetite Depressants,
pubmed-meshheading:11354363-Benzodiazepines,
pubmed-meshheading:11354363-Gallbladder,
pubmed-meshheading:11354363-Guinea Pigs,
pubmed-meshheading:11354363-Rats,
pubmed-meshheading:11354363-Rats, Long-Evans,
pubmed-meshheading:11354363-Receptor, Cholecystokinin A,
pubmed-meshheading:11354363-Receptors, Cholecystokinin,
pubmed-meshheading:11354363-Satiety Response
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pubmed:year |
2001
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pubmed:articleTitle |
1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.
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pubmed:affiliation |
Department of Medicinal Chemistry, Glaxo Welcome Research and Development, Research Triangle Park, NC 27709, USA. rgs13254@glaxowellcome.com
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pubmed:publicationType |
Journal Article,
In Vitro
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