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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-5-16
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pubmed:abstractText |
The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Isoindoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/tandospirone
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1141-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11354362-Drug Design,
pubmed-meshheading:11354362-Indicators and Reagents,
pubmed-meshheading:11354362-Isoindoles,
pubmed-meshheading:11354362-Kinetics,
pubmed-meshheading:11354362-Ligands,
pubmed-meshheading:11354362-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11354362-Models, Molecular,
pubmed-meshheading:11354362-Molecular Conformation,
pubmed-meshheading:11354362-Molecular Mimicry,
pubmed-meshheading:11354362-Piperazines,
pubmed-meshheading:11354362-Pyrimidines,
pubmed-meshheading:11354362-Receptors, Dopamine D2,
pubmed-meshheading:11354362-Receptors, Dopamine D4,
pubmed-meshheading:11354362-Receptors, Serotonin,
pubmed-meshheading:11354362-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:11354362-Serotonin Receptor Agonists,
pubmed-meshheading:11354362-Solutions
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pubmed:year |
2001
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pubmed:articleTitle |
Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.
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pubmed:affiliation |
Sumitomo Pharmaceuticals Research Division, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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