Linked Life Data

11353520

Source:http://linkedlifedata.com/resource/pubmed/id/11353520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-16
pubmed:abstractText
Studies were initiated to determine the effects of restricted (32.2 cm2 per mouse), normal (96.8 cm2), or excess floor space (129.0 cm2) allowances by using a model of three mice per cage. BALB/cJ mice were bred on-site and weaned at 3 weeks of age into specially designed polycarbonate shoebox cages modified to each space allowance. Cages contained aspen shavings for bedding, and mice were fed and watered ad libitum. Body weight gains, feed and water use, and immunologic measures largely were not effected by floor space allowances. Female BALB/cJ mice were heavier and had increased lymphocyte blastogenesis to phytohemagglutinin (20 microg/mL) when given 32.2 cm2/mouse than when given 129 cm2/mouse. Female mice showed an increase in grooming and sitting behaviors when given 32.2 cm2/mouse, but male mice with restricted floor space spent more time lying down but showed no change in grooming or sitting behaviors compared to mice given more space. Among male mice, limited floor space did not significantly influence growth rates, but male mice given 32.2 cm2/mouse had less mortality than did mice given more space. We conclude that floor spaces as limited as 32.2 cm2/mouse did not cause behavior, health, immune or performance problems for BALB/cJ mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1060-0558
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Floor space needs for laboratory mice: BALB/cJ males or females in solid-bottom cages with bedding.
pubmed:affiliation
Department of Animal Science, Texas Tech University, Lubbock, Texas 79409-2141, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't