Linked Life Data

11353142

Source:http://linkedlifedata.com/resource/pubmed/id/11353142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-5-15
pubmed:abstractText
The purpose of this study was to examine a broad range of toxicologic responses in rats exposed to a multi-component pollutant atmosphere. Cumulative and adaptive respiratory tract responses to 3 concentrations of an inhaled particle-oxidant mixture were examined in Fisher 344 N rats exposed 4 h/day, 3 days/week for 4 weeks. The mixtures contained O3, NO2, NH4HSO4, carbon particles, and HNO3 vapor. Irritant-induced, rapid-shallow breathing responses were present during the first 4-h exposure to medium and high concentrations. Successive exposures showed diminished responses in medium concentrations and exacerbated responses in high concentrations. At the end of 4 weeks, rats exposed to high concentrations exhibited lung lesions. Lavaged pulmonary macrophages showed dose-dependent depressions of Fc-receptor binding and phagocytosis. Lung tissue macrophages showed dose-dependent increases in acid phosphatase staining density and carbon particles. Respiratory tract clearance of tracer particles was not significantly affected by the exposures. Broncho-alveolar epithelial permeability was increased by the high concentration. Epithelial cell-proliferation labeling showed a dose-dependent increase at all levels of the respiratory tract. Progressively exacerbated breathing-pattern responses at high concentrations were associated with lung lesions and high cell-proliferation labeling in the nose transitional epithelium and terminal bronchioles. Attenuating or adaptive breathing-pattern responses occurred in the presence of smaller, but in many cases still significant, compromise of respiratory functions. Either attenuating or exacerbated breathing-pattern responses can occur in the presence of a significant dose-dependent compromise of other respiratory functions and lung tissue injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1096-6080
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-41
pubmed:dateRevised
2010-9-17
pubmed:meshHeading
pubmed-meshheading:11353142-Air Pollutants, pubmed-meshheading:11353142-Ammonium Sulfate, pubmed-meshheading:11353142-Animals, pubmed-meshheading:11353142-Bronchoalveolar Lavage Fluid, pubmed-meshheading:11353142-Carbon, pubmed-meshheading:11353142-Cell Division, pubmed-meshheading:11353142-Dose-Response Relationship, Drug, pubmed-meshheading:11353142-Drug Interactions, pubmed-meshheading:11353142-Inhalation Exposure, pubmed-meshheading:11353142-Lung, pubmed-meshheading:11353142-Macrophages, Alveolar, pubmed-meshheading:11353142-Male, pubmed-meshheading:11353142-Mucociliary Clearance, pubmed-meshheading:11353142-Nitric Acid, pubmed-meshheading:11353142-Nitrogen Dioxide, pubmed-meshheading:11353142-Oxidants, pubmed-meshheading:11353142-Ozone, pubmed-meshheading:11353142-Particle Size, pubmed-meshheading:11353142-Phagocytosis, pubmed-meshheading:11353142-Rats, pubmed-meshheading:11353142-Rats, Inbred F344, pubmed-meshheading:11353142-Respiratory System
pubmed:year
2001
pubmed:articleTitle
Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture.
pubmed:affiliation
Department of Biology, University of Hawaii at Hilo, Hilo, Hawaii 96720-4091, USA. mautz@hawaii.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't