Source:http://linkedlifedata.com/resource/pubmed/id/11352308
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2001-5-15
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pubmed:abstractText |
MENI is an inherited tumor syndrome characterized by the development of tumors of the parathyroid, the anterior pituitary and the pancreatic islets. Tumors of these endocrine glands in MEN1 patients demonstrate loss of heterozygosity (LOH) at the locus of the MEN1 tumor suppressor gene. Menin, the protein encoded by the MEN1 gene, is ubiquitously expressed in endocrine tissue, and less commonly these patients can present with tumors of other endocrine tissues, including thyroid and adrenal. We hypothesize that MEN1 gene mutation may be involved in the oncogenesis of other less common tumors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1068-9265
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
342-6
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pubmed:dateRevised |
2007-7-18
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pubmed:meshHeading |
pubmed-meshheading:11352308-Carcinoma, Papillary,
pubmed-meshheading:11352308-Genes, Tumor Suppressor,
pubmed-meshheading:11352308-Humans,
pubmed-meshheading:11352308-Hyperparathyroidism,
pubmed-meshheading:11352308-Loss of Heterozygosity,
pubmed-meshheading:11352308-Male,
pubmed-meshheading:11352308-Middle Aged,
pubmed-meshheading:11352308-Multiple Endocrine Neoplasia Type 1,
pubmed-meshheading:11352308-Polymerase Chain Reaction,
pubmed-meshheading:11352308-Tumor Markers, Biological
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pubmed:year |
2001
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pubmed:articleTitle |
Genetic analysis of a papillary thyroid carcinoma in a patient with MEN1.
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pubmed:affiliation |
The Department of Surgery, Stanford University School of Medicine, California 94305-5494, USA.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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