| pubmed-article:11349123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C1334292 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11349123 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:11349123 | pubmed:issue | 27 | lld:pubmed |
| pubmed-article:11349123 | pubmed:dateCreated | 2001-7-2 | lld:pubmed |
| pubmed-article:11349123 | pubmed:abstractText | Jak3 is responsible for growth signals by various cytokines such as interleukin (IL)-2, IL-4, and IL-7 through association with the common gamma chain (gammac) in lymphocytes. We found that T cells from Jak3-deficient mice exhibit impairment of not only cytokine signaling but also early activation signals and that Jak3 is phosphorylated upon T cell receptor (TCR) stimulation. TCR-mediated phosphorylation of Jak3 is independent of IL-2 receptor/gammac but is dependent on Lck and ZAP-70. Jak3 was found to be assembled with the TCR complex, particularly through direct association with CD3zeta via its JH4 region, which is a different region from that for gammac association. These results suggest that Jak3 plays a role not only in cell growth but also in T cell activation and represents cross-talk of a signaling molecule between TCR and growth signals. | lld:pubmed |
| pubmed-article:11349123 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11349123 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11349123 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11349123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11349123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11349123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11349123 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11349123 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:SaitoTT | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:TomitaKK | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:OhnoHH | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:YamasakiSS | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:MANNS JSJ | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:KuriyamaTT | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:SaijoKK | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:AraseHH | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:O'SheaJ JJJ | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:ShirasawaTT | lld:pubmed |
| pubmed-article:11349123 | pubmed:author | pubmed-author:NakatsuFF | lld:pubmed |
| pubmed-article:11349123 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11349123 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11349123 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11349123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11349123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11349123 | pubmed:pagination | 25378-85 | lld:pubmed |
| pubmed-article:11349123 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11349123 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11349123 | pubmed:articleTitle | Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex. | lld:pubmed |
| pubmed-article:11349123 | pubmed:affiliation | Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8790, Japan. | lld:pubmed |
| pubmed-article:11349123 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11349123 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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