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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2001-7-2
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pubmed:abstractText |
Jak3 is responsible for growth signals by various cytokines such as interleukin (IL)-2, IL-4, and IL-7 through association with the common gamma chain (gammac) in lymphocytes. We found that T cells from Jak3-deficient mice exhibit impairment of not only cytokine signaling but also early activation signals and that Jak3 is phosphorylated upon T cell receptor (TCR) stimulation. TCR-mediated phosphorylation of Jak3 is independent of IL-2 receptor/gammac but is dependent on Lck and ZAP-70. Jak3 was found to be assembled with the TCR complex, particularly through direct association with CD3zeta via its JH4 region, which is a different region from that for gammac association. These results suggest that Jak3 plays a role not only in cell growth but also in T cell activation and represents cross-talk of a signaling molecule between TCR and growth signals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/CD3 antigen, zeta chain,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/JAK3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Zap70 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:AraseHH,
pubmed-author:KuriyamaTT,
pubmed-author:MANNS JSJ,
pubmed-author:NakatsuFF,
pubmed-author:O'SheaJ JJJ,
pubmed-author:OhnoHH,
pubmed-author:SaijoKK,
pubmed-author:SaitoTT,
pubmed-author:ShirasawaTT,
pubmed-author:TomitaKK,
pubmed-author:YamasakiSS
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25378-85
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11349123-Animals,
pubmed-meshheading:11349123-Antigens, CD3,
pubmed-meshheading:11349123-Calcium,
pubmed-meshheading:11349123-Cytokines,
pubmed-meshheading:11349123-Enzyme Activation,
pubmed-meshheading:11349123-Humans,
pubmed-meshheading:11349123-Janus Kinase 3,
pubmed-meshheading:11349123-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:11349123-Mice,
pubmed-meshheading:11349123-Phosphorylation,
pubmed-meshheading:11349123-Protein-Tyrosine Kinases,
pubmed-meshheading:11349123-Rabbits,
pubmed-meshheading:11349123-Receptors, Antigen, T-Cell,
pubmed-meshheading:11349123-Receptors, Interleukin-2,
pubmed-meshheading:11349123-Spleen,
pubmed-meshheading:11349123-T-Lymphocytes,
pubmed-meshheading:11349123-Transfection,
pubmed-meshheading:11349123-Tumor Cells, Cultured,
pubmed-meshheading:11349123-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
2001
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pubmed:articleTitle |
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex.
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pubmed:affiliation |
Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8790, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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