Source:http://linkedlifedata.com/resource/pubmed/id/11348227
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2001-5-11
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pubmed:abstractText |
[reaction in text] A new method for the synthesis of selenocysteine derivatives and selenocysteine-containing peptides is described. Fmoc-Se-p-methoxybenzylselenocysteine (1) was prepared and used for solid-phase synthesis of peptides with an N-terminal unprotected selenocysteine. Subsequent native chemical ligation with a peptide thioester provided a 17-mer that corresponds to the C-terminus of ribonucleotide reductase with selenocysteine in place of cysteine.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1523-7060
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1331-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11348227-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11348227-Molecular Structure,
pubmed-meshheading:11348227-Peptides,
pubmed-meshheading:11348227-Ribonucleotide Reductases,
pubmed-meshheading:11348227-Selenocysteine,
pubmed-meshheading:11348227-Sequence Analysis, Protein,
pubmed-meshheading:11348227-Sequence Homology, Amino Acid,
pubmed-meshheading:11348227-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis of a selenocysteine-containing peptide by native chemical ligation.
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pubmed:affiliation |
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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