Linked Life Data

11348175

Source:http://linkedlifedata.com/resource/pubmed/id/11348175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2001-5-11
pubmed:abstractText
[reaction: see text]. The total synthesis of the potent immunosuppressant FR901483 is described. In a key step, the intermolecular Diels-Alder cycloaddition of an amidoacrolein with 2-(triisopropylsilyloxy)-1,3-butadiene produced the desired 3-cyclohexene-1-carboxaldehyde. This compound was subjected to basic followed by acidic conditions which effected two sequential aldol cyclizations to deliver the tricyclic ring system of the natural product, suitably functionalized for completion of the total synthesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1523-7060
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1125-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Total synthesis of the immunosuppressant FR901483 via an amidoacrolein cycloaddition.
pubmed:affiliation
Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16801, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.