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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-5-10
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pubmed:abstractText |
Previous studies demonstrated that hydrogen peroxide (H(2)O(2)) is a tumor promoter in the rat liver epithelial cell line T51B. We investigated the pathway linking H(2)O(2) to tumor promotion. H(2)O(2) can directly induce tyrosine phosphorylation of epidermal growth factor receptor (EGFR). H(2)O(2) and epidermal growth factor exerted similar effects on the induction of early growth response genes, disruption of gap junction communication, triggering of calcium inflow, and promotion of transformation. Furthermore, the effect of H(2)O(2) on tumor promotion was blocked by abrogation of EGFR activation. Our results suggested that tumor promotion by H(2)O(2) is mediated mainly through activation of EGFR in T51B cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Connexins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Egr1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0899-1987
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-17
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11346883-Animals,
pubmed-meshheading:11346883-Apoptosis,
pubmed-meshheading:11346883-Blotting, Northern,
pubmed-meshheading:11346883-Blotting, Western,
pubmed-meshheading:11346883-Calcium,
pubmed-meshheading:11346883-Cell Survival,
pubmed-meshheading:11346883-Cell Transformation, Neoplastic,
pubmed-meshheading:11346883-Colony-Forming Units Assay,
pubmed-meshheading:11346883-Connexins,
pubmed-meshheading:11346883-DNA-Binding Proteins,
pubmed-meshheading:11346883-Early Growth Response Protein 1,
pubmed-meshheading:11346883-Enzyme Activation,
pubmed-meshheading:11346883-Enzyme Inhibitors,
pubmed-meshheading:11346883-Epidermal Growth Factor,
pubmed-meshheading:11346883-Epithelial Cells,
pubmed-meshheading:11346883-Hydrogen Peroxide,
pubmed-meshheading:11346883-Immediate-Early Proteins,
pubmed-meshheading:11346883-Liver,
pubmed-meshheading:11346883-Phosphorylation,
pubmed-meshheading:11346883-Precipitin Tests,
pubmed-meshheading:11346883-Protein-Tyrosine Kinases,
pubmed-meshheading:11346883-Rats,
pubmed-meshheading:11346883-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11346883-Transcription Factors,
pubmed-meshheading:11346883-Tyrosine
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pubmed:year |
2001
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pubmed:articleTitle |
Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor.
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pubmed:affiliation |
Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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