Linked Life Data

11345199

Source:http://linkedlifedata.com/resource/pubmed/id/11345199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-9
pubmed:abstractText
It is generally believed that quiescent CD4+ T cells are not susceptible to HIV-1 infection. However, infection of unstimulated peripheral mononuclear cells by syncytial-inducing (SI) viruses has been shown to be much more efficient than with non-syncytial-inducing (NSI) viruses. This suggested that SI, CXCR4-tropic viruses may be able to infect quiescent CD4+ T cells. We studied the infection of highly purified quiescent CD4+ T cells by SI and NSI viruses. In this article we show that although NSI viruses failed to significantly infect quiescent cells, SI viruses consistently infected these cells and produced viruses upon cellular activation by interleukin-2, 2 to 7 days after initial infection. To examine whether the difference was the result of viral or host factors, we purified CCR5+ quiescent CD4+ T cells and showed that these cells can be infected by dual tropic (R5X4) but not by R5 virus. This indicated that CCR5+ quiescent T cells were also susceptible to HIV-1 infection, and the failure of NSI, CCR5-tropic viruses to infect quiescent cells may be due to some intrinsic properties of these viruses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0925-5710
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Differential susceptibility of quiescent CD4+ lymphocytes to syncytial-inducing and non-syncytial-inducing isolates of HIV-1.
pubmed:affiliation
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sipaw@mahidol.ac.th
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't