Linked Life Data

11343832

Source:http://linkedlifedata.com/resource/pubmed/id/11343832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-5-9
pubmed:abstractText
The peptide-transporter PEPT2 mediates electrogenic uphill transport of di- and tripeptides, selected peptidomimetics and delta aminolevulinic acid. The transporter was cloned from rat central nervous tissue recently and its mRNA was localized to astrocytes. In the present studies the expression of PEPT2-protein and -mRNA in rat dorsal root ganglia was investigated. Immunohistochemistry revealed PEPT2-immunoreactivity in satellite glial cells surrounding the ganglionic neurons. There was no expression in neuronal cells. In-situ-hybridization studies colocalized the expression of PEPT2-mRNA to satellite cells. This is the first report on the expression of PEPT2-protein in the peripheral nervous system where PEPT2 may serve as uptake system for products of protein degradation, for removal of biologically active short-chain peptides and non-peptides such as delta aminolevulinic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
304
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia.
pubmed:affiliation
Department of Pediatric Pneumology and Immunology, Charité Campus Virchow, Humboldt-University, Augustenburger Platz 1, D-13353 Berlin, Germany.
pubmed:publicationType
Journal Article