Source:http://linkedlifedata.com/resource/pubmed/id/11343206
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2001-5-8
|
| pubmed:abstractText |
The in vitro lymphocyte proliferative response (LPR) and interferon (IFN)-gamma production in the presence of Toxoplasma antigen were evaluated in 97 human immunodeficiency virus (HIV)-1-infected patients with CD4 cell counts of <100 cells/microL (group 1), currently >300 cells/microL but previously <100 cells/microL (group 2), or always >300 cells/microL (group 3) and in 28 non-HIV-infected blood donors (group 4), all seropositive to Toxoplasma. In group 2, 81% of patients had a positive LPR, versus 20% in group 1 (P<10(-3)). IFN-gamma production was greater in group 2 than in group 1 (922 vs. 0 Deltapg/mL; P=10(-4)). Multivariate analysis found a significant association between a positive LPR to Toxoplasma antigen and a CD4 count >300 cells/microL (odds ratio [OR], 16.3; 95% confidence interval [CI], 5.3-50.2) and anti-Toxoplasma IgG titer >150 IU/mL (OR, 5; 95% CI, 1.6-15.2). Immune reconstitution under highly active antiretroviral therapy was associated with a restoration of immune responses against Toxoplasma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
183
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1586-91
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11343206-Adult,
pubmed-meshheading:11343206-Animals,
pubmed-meshheading:11343206-Anti-HIV Agents,
pubmed-meshheading:11343206-Antigens, Protozoan,
pubmed-meshheading:11343206-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:11343206-CD4 Lymphocyte Count,
pubmed-meshheading:11343206-Cross-Sectional Studies,
pubmed-meshheading:11343206-Female,
pubmed-meshheading:11343206-HIV Infections,
pubmed-meshheading:11343206-HIV-1,
pubmed-meshheading:11343206-Humans,
pubmed-meshheading:11343206-Immunocompromised Host,
pubmed-meshheading:11343206-Interferon-gamma,
pubmed-meshheading:11343206-Lymphocyte Activation,
pubmed-meshheading:11343206-Lymphocytes,
pubmed-meshheading:11343206-Male,
pubmed-meshheading:11343206-Middle Aged,
pubmed-meshheading:11343206-Toxoplasma
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Immune recovery under highly active antiretroviral therapy is associated with restoration of lymphocyte proliferation and interferon-gamma production in the presence of Toxoplasma gondii antigens.
|
| pubmed:affiliation |
Department of Infectious Diseases, Saint Louis Hospital, Paris, France. sandra.fournier2@libertysurf.fr
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|