| pubmed-article:11343125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0035868 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0035681 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0302523 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0700325 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:11343125 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:11343125 | pubmed:issue | 6816 | lld:pubmed |
| pubmed-article:11343125 | pubmed:dateCreated | 2001-5-8 | lld:pubmed |
| pubmed-article:11343125 | pubmed:abstractText | Helical filaments driven by linear molecular motors are anticipated to rotate around their axis, but rotation consistent with the helical pitch has not been observed. 14S dynein and non-claret disjunctional protein (ncd) rotated a microtubule more efficiently than expected for its helical pitch, and myosin rotated an actin filament only poorly. For DNA-based motors such as RNA polymerase, transcription-induced supercoiling of DNA supports the general picture of tracking along the DNA helix. Here we report direct and real-time optical microscopy measurements of rotation rate that are consistent with high-fidelity tracking. Single RNA polymerase molecules attached to a glass surface rotated DNA for >100 revolutions around the right-handed screw axis of the double helix with a rotary torque of >5 pN nm. This real-time observation of rotation opens the possibility of resolving individual transcription steps. | lld:pubmed |
| pubmed-article:11343125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11343125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343125 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11343125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11343125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11343125 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11343125 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:ItohHH | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:ShimamotoNN | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:HaradaYY | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:TakatsukaYY | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:KinositaKKJr | lld:pubmed |
| pubmed-article:11343125 | pubmed:author | pubmed-author:OharaOO | lld:pubmed |
| pubmed-article:11343125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11343125 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:11343125 | pubmed:volume | 409 | lld:pubmed |
| pubmed-article:11343125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11343125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11343125 | pubmed:pagination | 113-5 | lld:pubmed |
| pubmed-article:11343125 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11343125 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11343125 | pubmed:articleTitle | Direct observation of DNA rotation during transcription by Escherichia coli RNA polymerase. | lld:pubmed |
| pubmed-article:11343125 | pubmed:affiliation | Department of Physics, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan. yharada@rinshoken.or.jp | lld:pubmed |
| pubmed-article:11343125 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11343125 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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