Source:http://linkedlifedata.com/resource/pubmed/id/11342969
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2001-5-8
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| pubmed:abstractText |
Diabetic cystopathy resulting from sensory neuropathy may potentially be treated by direct gene therapy. It has been suggested that nerve growth factor (NGF) has an ameliorative effect in preventing the death in diabetes of afferent dorsal root ganglion neurons, which control bladder function. We investigated NGF gene transfer to the bladder and bladder afferent pathways for treating diabetic cystopathy. We used replication competent and replication defective herpes simplex virus type 1 (HSV-1) vectors that express a functionally active form of the beta-subunit of mouse NGF (beta-NGF) to examine the level and duration of therapeutic gene expression after administration of the vectors.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0022-5347
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
165
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1748-54
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11342969-Animals,
pubmed-meshheading:11342969-Diabetes Mellitus, Experimental,
pubmed-meshheading:11342969-Diabetic Neuropathies,
pubmed-meshheading:11342969-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11342969-Female,
pubmed-meshheading:11342969-Fluorescent Antibody Technique,
pubmed-meshheading:11342969-Ganglia, Spinal,
pubmed-meshheading:11342969-Gene Therapy,
pubmed-meshheading:11342969-Gene Transfer Techniques,
pubmed-meshheading:11342969-Genetic Vectors,
pubmed-meshheading:11342969-Herpesvirus 1, Human,
pubmed-meshheading:11342969-Nerve Growth Factor,
pubmed-meshheading:11342969-Neurons, Afferent,
pubmed-meshheading:11342969-Rats,
pubmed-meshheading:11342969-Rats, Sprague-Dawley,
pubmed-meshheading:11342969-Urinary Bladder,
pubmed-meshheading:11342969-Urinary Bladder, Neurogenic
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| pubmed:year |
2001
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| pubmed:articleTitle |
Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction.
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| pubmed:affiliation |
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|