Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-5-8
pubmed:abstractText
Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5909-16
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11342605-Adoptive Transfer, pubmed-meshheading:11342605-Amino Acid Sequence, pubmed-meshheading:11342605-Animals, pubmed-meshheading:11342605-Cytokines, pubmed-meshheading:11342605-Disease Progression, pubmed-meshheading:11342605-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:11342605-Epitopes, T-Lymphocyte, pubmed-meshheading:11342605-Female, pubmed-meshheading:11342605-Genetic Predisposition to Disease, pubmed-meshheading:11342605-Hypersensitivity, Delayed, pubmed-meshheading:11342605-Immunity, Innate, pubmed-meshheading:11342605-Immunoglobulin G, pubmed-meshheading:11342605-Injections, Intradermal, pubmed-meshheading:11342605-Leptin, pubmed-meshheading:11342605-Mice, pubmed-meshheading:11342605-Mice, Inbred C57BL, pubmed-meshheading:11342605-Mice, Obese, pubmed-meshheading:11342605-Molecular Sequence Data, pubmed-meshheading:11342605-Myelin Proteins, pubmed-meshheading:11342605-Myelin-Associated Glycoprotein, pubmed-meshheading:11342605-Recombinant Proteins, pubmed-meshheading:11342605-T-Lymphocyte Subsets, pubmed-meshheading:11342605-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:11342605-Vaccination
pubmed:year
2001
pubmed:articleTitle
Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.
pubmed:affiliation
Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli "Federico II," Napoli, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't