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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-5-8
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pubmed:abstractText |
Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase in the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5869-73
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11342599-Acute Disease,
pubmed-meshheading:11342599-Animals,
pubmed-meshheading:11342599-Antigens,
pubmed-meshheading:11342599-Antigens, Surface,
pubmed-meshheading:11342599-Chromosome Mapping,
pubmed-meshheading:11342599-Female,
pubmed-meshheading:11342599-Ganglia, Sensory,
pubmed-meshheading:11342599-Genetic Markers,
pubmed-meshheading:11342599-Herpes Simplex,
pubmed-meshheading:11342599-Immunity, Innate,
pubmed-meshheading:11342599-Killer Cells, Natural,
pubmed-meshheading:11342599-Lectins, C-Type,
pubmed-meshheading:11342599-Lethal Dose 50,
pubmed-meshheading:11342599-Mice,
pubmed-meshheading:11342599-Mice, Congenic,
pubmed-meshheading:11342599-Mice, Inbred BALB C,
pubmed-meshheading:11342599-Mice, Inbred C57BL,
pubmed-meshheading:11342599-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:11342599-Neurons,
pubmed-meshheading:11342599-Peripheral Nerves,
pubmed-meshheading:11342599-Phenotype,
pubmed-meshheading:11342599-Proteins,
pubmed-meshheading:11342599-Skin,
pubmed-meshheading:11342599-Species Specificity,
pubmed-meshheading:11342599-Viral Load,
pubmed-meshheading:11342599-Virus Latency
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pubmed:year |
2001
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pubmed:articleTitle |
Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons.
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pubmed:affiliation |
Pediatric Virology and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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