Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-5-8
pubmed:abstractText
This work aims to demonstrate that CD4(+)CD56(+) malignancies arise from transformed cells of the lymphoid-related plasmacytoid dendritic cell (pDC) subset. The analysis of malignant cells from 7 patients shows that in all cases, like pDCs, leukemic cells are negative for lineage markers CD3, CD19, CD13, CD33, and CD11c but express high levels of interleukin-3 receptor alpha chain (IL-3Ralpha), HLA-DR, and CD45RA. Tumor cells produce interferon-alpha in response to influenza virus, while upon maturation with IL-3 they become a powerful inducer of naive CD4(+) T-cell proliferation and promote their T-helper 2 polarization. As pDCs, leukemic cells also express pre-Talpha and lambda-like 14.1 transcripts, arguing in favor of a lymphoid origin. In addition, malignant cells express significant levels of CD56 and granzyme B. Overall, those observations suggest that CD4(+)CD56(+) leukemic cells could represent the malignant counterpart of pDCs, both of which are closely related to B, T, and NK cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56, http://linkedlifedata.com/resource/pubmed/chemical/GZMB protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage..., http://linkedlifedata.com/resource/pubmed/chemical/Granzymes, http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-3, http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3210-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11342451-Adolescent, pubmed-meshheading:11342451-Adult, pubmed-meshheading:11342451-Aged, pubmed-meshheading:11342451-Aged, 80 and over, pubmed-meshheading:11342451-Antigens, CD4, pubmed-meshheading:11342451-Antigens, CD40, pubmed-meshheading:11342451-Antigens, CD45, pubmed-meshheading:11342451-Antigens, CD56, pubmed-meshheading:11342451-Cell Differentiation, pubmed-meshheading:11342451-Child, pubmed-meshheading:11342451-Dendritic Cells, pubmed-meshheading:11342451-Female, pubmed-meshheading:11342451-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:11342451-Granzymes, pubmed-meshheading:11342451-HLA-DR Antigens, pubmed-meshheading:11342451-Humans, pubmed-meshheading:11342451-Interferon-alpha, pubmed-meshheading:11342451-Interleukin-3, pubmed-meshheading:11342451-Leukemia, pubmed-meshheading:11342451-Male, pubmed-meshheading:11342451-Middle Aged, pubmed-meshheading:11342451-Receptors, Interleukin-3, pubmed-meshheading:11342451-Serine Endopeptidases, pubmed-meshheading:11342451-T-Lymphocytes, pubmed-meshheading:11342451-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:11342451-Transfection, pubmed-meshheading:11342451-Tumor Cells, Cultured
pubmed:year
2001
pubmed:articleTitle
Identification of a leukemic counterpart of the plasmacytoid dendritic cells.
pubmed:affiliation
Department of Research and Development, Research Group on Lymphoma, EFS Rhône-Alpes Grenoble, La Tronche, France. laurence.chaperot@efs.sante.fr
pubmed:publicationType
Journal Article