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rdf:type |
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lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205250,
umls-concept:C1283195,
umls-concept:C1334043,
umls-concept:C1417166,
umls-concept:C1421311,
umls-concept:C1522424,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2001-5-8
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pubmed:databankReference |
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pubmed:abstractText |
Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose predicted amino acid sequence shows 95% identity to mouse UCH-L3 and 94% identity to human UCH-L3. Genomic structure, chromosome localization, and expression pattern of Uchl3 and Uchl4 were characterized in the mouse. Both Uchl3 and Uchl4 were expressed in various tissues examined; however, expression level was quite lower in Uchl4. While Uchl3 consists of at least 9 exons spanning about 12 kb, Uchl4 was an intronless gene with a size of about 2 kb. By PCR-based analysis with T31 radiation hybrid mapping panel, Uchl3 and Uchl4 were mapped on mouse chromosome 9 and 14, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
627-33
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pubmed:dateRevised |
2008-3-3
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pubmed:meshHeading |
pubmed-meshheading:11341770-Amino Acid Sequence,
pubmed-meshheading:11341770-Animals,
pubmed-meshheading:11341770-Base Sequence,
pubmed-meshheading:11341770-Chromosome Mapping,
pubmed-meshheading:11341770-Cloning, Molecular,
pubmed-meshheading:11341770-DNA, Complementary,
pubmed-meshheading:11341770-DNA Primers,
pubmed-meshheading:11341770-Exons,
pubmed-meshheading:11341770-Gene Expression,
pubmed-meshheading:11341770-Humans,
pubmed-meshheading:11341770-Introns,
pubmed-meshheading:11341770-Male,
pubmed-meshheading:11341770-Mice,
pubmed-meshheading:11341770-Mice, Inbred C57BL,
pubmed-meshheading:11341770-Molecular Sequence Data,
pubmed-meshheading:11341770-RNA, Messenger,
pubmed-meshheading:11341770-Sequence Homology, Amino Acid,
pubmed-meshheading:11341770-Species Specificity,
pubmed-meshheading:11341770-Thiolester Hydrolases,
pubmed-meshheading:11341770-Tissue Distribution,
pubmed-meshheading:11341770-Ubiquitin Thiolesterase
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pubmed:year |
2001
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pubmed:articleTitle |
Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3.
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pubmed:affiliation |
Department of Degenerative Neurological Diseases, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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