rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1975-8-18
|
pubmed:abstractText |
1. The membrane resistance of isolated salivary glands was found to decrease in response to 5-HT. The change in resistance was calcium-dependent. 2. The resistance change of the apical membrane was found to be much greater than the change in resistance of the basal membrane. 3. Potential responses under current-clamped conditions showed that one part of the biphasic response to 5-HT (attributed to an increase in chloride permeability) could be reversed and the other part (attributed to an increase in a potassium pump) could not. 4. These observations have been incorporated into a model which, on evaluation, predicts all of the observed potential changes during the action of 5-HT. It suggests that the potential responses reflect changes in the internal chloride concentration produced by the calcium-dependent increases in chloride permeability.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-3751
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
244
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
549-67
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:1133770-Animals,
pubmed-meshheading:1133770-Calcium,
pubmed-meshheading:1133770-Cell Membrane,
pubmed-meshheading:1133770-Cell Membrane Permeability,
pubmed-meshheading:1133770-Chlorides,
pubmed-meshheading:1133770-Culture Media,
pubmed-meshheading:1133770-Diptera,
pubmed-meshheading:1133770-Electric Conductivity,
pubmed-meshheading:1133770-Electric Stimulation,
pubmed-meshheading:1133770-Membrane Potentials,
pubmed-meshheading:1133770-Microelectrodes,
pubmed-meshheading:1133770-Models, Biological,
pubmed-meshheading:1133770-Salivary Glands,
pubmed-meshheading:1133770-Serotonin
|
pubmed:year |
1975
|
pubmed:articleTitle |
Membrane permeability changes during stimulation of isolated salivary glands of Calliphora by 5-hydroxytryptamine.
|
pubmed:publicationType |
Journal Article,
In Vitro
|